School of Biotechnology (August 2021)

On Sep 8, 2021

Journal Papers

1. Sethy, C., Goutam, K., Das, B., Dash, S. R. and Kundu, C. N. (2021), Nectin-4 Promotes Lymphangiogenesis and Lymphatic Metastasis in Breast Cancer by Regulating CXCR4-LYVE-1 Axis, Vascular Pharmacology, No. 106865,DOI: 10.1016/j.vph.2021.106865(IF 5.773).

Abstract: The role of Nectin-4 in lymphangiogenesis is unknown. Here, we systematically delineated the role of Nectin-4 in lymphangiogenesis and its regulation in invasive duct carcinoma (IDC). Nectin-4 expression positively correlated with CXCR4 expression, and LYVE-1-lymphatic vessel density (LVD). LVD was significantly higher in axillary lymph node (ALN) than primary tumor. Nectin-4 stimulated the expressions of CXCR4 and CXCL12 under hypoxic conditions in ALN derived primary cells. Further, Nectin-4 augmented expressions of lymphatic metastatic markers (e.g. eNOS, TGF-β, CD-105) and MMPs. Thus, Nectin-4 displayed a predominant role in promoting tumor-induced lymphangiogenesis and lymphatic metastasis by modulating CXCR4/CXCL12-LYVE-1- axis.

2. Molla, S., Chatterjee, S., Sethy, C., Sinha, S. and Kundu, C. N. (2021), OlaparibEnhances Curcumin-Mediated Apoptosis in Oral Cancer Cells by Inducing PARP Trapping through Modulation of BER and Chromatin Assembly, DNA Repair, No. 103157, DOI: 10.1016/j.dnarep.2021.103157(IF 4.913).

Abstract: To study the detailed mechanism of anti-cancer action through PARP trapping, we have treated oral cancer cells with curcumin (Cur), olaparib (Ola) and their combination (Cur+Ola). Cur+Ola treatment triggered the expressions of PARP-1 and APC and down regulated other base excision repair (BER) proteins in the chromatin fraction but not in the nuclear fraction. Interestingly, complete abolishment ALC1 decreased expression of Histone H3 and P300 was noted in chromatin of Cur + Ola treated cells. Thus, the present study reveals that Cur+Ola treatment increased oral cancer cell death predominantly through PARP-1 trapping and indirect inhibition of chromatin remodelling.

3. Sisodiya, S., Paul, S., Chaudhary, H., Grewal, P., Kumar, G., Daniel, D. P., Das, B., Nayak, D., Guchhait, S. K., Kundu, C. N. and Banerjee, U. C. (2021), Exploration of Benzo [B] Carbazole-6, 11-Diones as Anticancer Agents: Synthesis and Studies of Htopoiiα Inhibition and Apoptotic Effects, Bioorganic & Medicinal Chemistry Letters, No. 128274, DOI: 10.1016/j.bmcl.2021.128274(IF 2.823).

Abstract: Two series of (hetero)arylamino-naphthoquinones and benzo-fused carbazolequinones were considered for study with the rationale that related structural motifs are present in numerous drugs, clinical trial agents, natural products and hTopoIIα inhibitors. Total 42 compounds were synthesized by reactions including dehydrogenative C-N and Pd-catalyzed C-C bond forming transformations. These compounds were screened against numerous cancer cells and normal cells. Some of the active compounds were evaluated for cell survival and apoptotic effects in cancer. All compounds were tested for hTopoIIα inhibitory activity. The investigated series compounds showed anti-cancer efficacy and relatively less cytotoxicity to normal cells.

4. Sinha, S. and Kundu, C. N. (2021), Cancer and COVID-19: Why Are Cancer Patients More Susceptible to COVID-19?, Med Oncol, Vol. 38, No. 9, p. 101, DOI: 10.1007/s12032-021-01553-3. (IF 3.064).

Abstract: The COVID-19 pandemic has engulfed the entire world and has claimed more than 3 million lives worldwide. The severity of the disease increases with age and presence of comorbidities, including cancer. Multiple clinical studies have shown that the cancer patients are highly susceptible to the severe form of the viral disease. In this review article, we have summarized the available scientific literature regarding the molecular links between COVID-19 and cancer, which make the cancer patients highly susceptible to COVID-19. Additionally, we have also discussed whether SARS-CoV-2 can contribute to cancer development in COVID-19 patients.

5. Dey, G. and Mookherjee, S. (2021), Probiotics-Targeting New Milestones from Gut Health to Mental Health, FEMS Microbiology Letters, Vol. 368, No. 15, DOI: 10.1093/femsle/fnab096 (IF: 2.7).

Abstract: Development of probiotic foods and formulations for neural health benefits has garnered interest, with a renewed focus. In this context, this review discusses the evidences collected on the anxiolytic and antidepressant effects of probiotics, especially during 2015-till now. Although more clinical trials are necessary to elucidate the exact mechanism of probiotic mode of action, several of the established probiotic strains have been investigated. It appears that few of them have demonstrated their potential as ‘psychobiotics’. In near future, biological effect of probiotics on neurological conditions can open up an entire avenue for personalized medication and healthcare in mental health.